Thu Oct 26 2023

37 articles - From Thursday Oct 19 2023 to Thursday Oct 26 2023

parm_toc.knit

Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Liver Transpl

Reply: The urgent need for consensus around organ donation after assisted dying.

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Meta-analysis

meta-analyses and systematic reviews

Am J Clin Nutr

Criterion validation of nutrient profiling systems: a systematic review and meta-analysis.

We found limited criterion-validation studies compared to the number of NPSs estimated to exist. Greater emphasis on conducting and reporting on criterion validation studies across varied contexts may improve the confidence in existing NPSs. Registry/Registry number PROSPERO, CRD42022343317.

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The effects of time-restricted eating vs habitual diet on inflammatory cytokines and adipokines in the general adult population: A systematic review with meta-analysis.

TRE may be an effective approach to reduce TNF-a and leptin levels in the general adult population.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Clin Nutr

Choline metabolites and incident cardiovascular disease in a prospective cohort of adults: Coronary Artery Risk Development in Young Adults (CARDIA) Study.

Our findings are consistent with a positive association between plasma choline and incident CVD. Among participants with lower kidney function, TMAO was positively, and betaine negatively, associated with CVD. These results further our understanding of the potential role for choline metabolism on CVD risk.

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Higher ultra-processed food intake is associated with adverse liver outcomes: a prospective cohort study of UK Biobank participants.

Higher UPF intake is associated with an increased risk of NAFLD, liver fibrosis and cirrhosis, and severe liver disease, and adverse levels of multiple clinical biomarkers, suggesting the potential importance of reducing UPF intake to improve liver health.

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Metabolic adaptation is associated with a greater increase in appetite following weight loss: a longitudinal study.

A larger metabolic adaptation during weight loss is accompanied by a greater drive to eat. This might help explain the inter-individual differences in weight loss outcomes to dietary interventions.

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Inflamm Bowel Dis

Are Depression and Anxiety Underdiagnosed in Socially Vulnerable Patients With Inflammatory Bowel Disease?

Disparities in the diagnoses of depression and anxiety for socially vulnerable patients with IBD exist. Awareness of these inequities is the first step toward developing interventions to improve mental health screening, eliminate barriers and bias, and promote referrals for appropriate mental health management.

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Dysregulated Immunity to Clostridioides difficile in IBD Patients Without a History of Recognized Infection.

These data suggest that IBD patients, potentially due to underlying intestinal dysbiosis, experience undiagnosed C. difficile infections that result in impaired toxin-specific immunity. This may contribute to the development of inflammatory T cell responses toward commensal bacteria and provide a rationale for C. difficile testing in IBD patients.

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Enteric Infection at Flare of Inflammatory Bowel Disease Impacts Outcomes at 2 Years.

Enteric infection at flare-specifically with CDI-is associated with worse IBD outcomes at 2 years. The relationship between E. coli subtypes at flare and subsequent IBD outcomes requires further investigation.

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Inflammatory Bowel Disease in Adults and Elderly: The Use of Selected Non-IBD Medication Examined in a Nationwide Cohort Study.

In al 3 age groups, the proportions of patients with redeemed prescriptions for several groups of non-IBD medication were significantly increased after the IBD diagnosis compared with before. The risk of becoming an incident user for several groups of non-IBD medication was increased in elderly patients.

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Longitudinal Trends in Pregnancy Outcomes Among Women With Inflammatory Bowel Disease in the Era of Biologics: A 20-Year Nationwide Analysis.

Over a 20-year period, live deliveries amongst women with IBD have increased. Trends in pregnancy outcomes have followed a similar trajectory in patients with and without IBD. However, there is still demonstrable risk of adverse pregnancy outcomes in patients with IBD.

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Obesity, Sarcopenia and Myosteatosis: Impact on Clinical Outcomes in the Operative Management of Crohn's Disease.

Myosteatosis is associated with nutritional impairment and predicts increased overall postoperative morbidity following resection for CD. Despite its association with specific increased postoperative risks, increased adiposity does not increase overall morbidity, reflecting preservation of nutritional status and relatively more quiescent disease phenotype. Impaired muscle mass and function represent an appealing target for patient optimization to improve outcomes in the surgical management of CD.

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Plasma Extracellular Vesicle LncRNA H19 as a Potential Diagnostic Biomarker for Inflammatory Bowel Diseases.

Our study suggests that circulating EV-lncRNA H19 exhibited promising potential for the diagnosis of active IBD.

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J Crohns Colitis

Analysis of Clinical Trial Screen Failures in Inflammatory Bowel Diseases (IBD): Real World Results from the International Organization for the study of IBD.

This first multicenter study analyzing reasons for non-enrollment in IBD RCTs shown that we lose patients at each step. Eligibility criteria, the risk of placebo assignment and insufficient disease activity were part of the main barriers.

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Frailty screening associates with hospitalization and decline in quality of life and functional status in older patients with inflammatory bowel disease.

Frailty screening associates with worse health outcomes in older patients with IBD. Further studies are needed to assess feasibility and effectiveness of implementation in routine care.

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Janus kinase inhibitors differentially inhibit specific cytokine signals in the mesenteric lymph node cells of IBD patients.

Despite their similarities, differences exist in the relative potencies of different JAKinibs against distinct cytokine families to explain their clinical efficacy.

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Lymphoma In Patients With Inflammatory Bowel Disease: A Multicenter Collaborative Study Between Getaid And Lysa.

Lymphomas occurring in IBD patients do not seem to have a worse outcome than in patients without IBD. Due to the scarcity of this situation, those patients should be managed in expert centers.

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Matrix metalloproteinases in intestinal fibrosis.

The exact regulation and role(s) of these MMPs in fibrosis are far from understood. Here, we review the current literature about ECM remodeling by MMPs in intestinal fibrosis and their potential role as biomarkers for disease progression or druggable targets.

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Ozanimod-Exposed Patients with Ulcerative Colitis Undergoing Total Colectomy Exhibit Unique Lymph Node Histologic Changes.

This study identifies unique histologic changes in the lymph nodes of patients with UC treated with ozanimod. The presence of sinus histiocytosis and dilated sinuses is in keeping with the known mechanism of action of ozanimod and suggests that blocking lymphocyte egression from lymph nodes was insufficient to ameliorate disease severity in these patients. The possibility of Castleman-like features identified in several of the cases, needs to be further investigated.

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Liver Transpl

Psychosocial evaluation of living liver Donors- State of current practices in the US.

Psycho-social contraindications to living liver donation vary amongst the transplant programs. Mental health follow-up of donor candidates is not standardized.

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Pancreas

Historical Review of Acute Pancreatitis Research Over the Last 80 Years.

Over the past 80 years, the pathogenesis, treatment, risk management, and experimental model were the main research highlights. Optimal supportive management, minimally invasive treatment, and prediction of prognosis are subjects of interest for clinical practitioners; signal transduction to identify a target for precise treatment is the focus of experimental research in AP.

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Pancreatology

Acute pancreatitis in Turkey: Results of a nationwide multicenter study.

This prospective study provides an extensive report on clinical characteristics, management and outcomes of AP in real-world practice. Mortality remains high in severe cases and physicians' adherence to guidelines during management of the disease needs improvement in some aspects.

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Comparison of different intensive triglyceride-lowering therapies in patients with hyperlipidemic acute pancreatitis.

Early CVVH lowers TG levels more efficiently than NS alone or CT therapy, but is not superior in terms of clinical outcomes and costs. NS also lowers TG levels and is significantly less costly than the other two treatments. Further multicenter studies are needed to determine the feasibility of NS alone treatment for HLAP patients.

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Determinants and outcomes of acute pancreatitis in patients hospitalized for COVID-19: Early pandemic experience.

In hospitalized patients with COVID-19, the presence of AP is associated with increased mortality and morbidity. Risk factors for developing AP in this population include Hispanic ethnicity, residence in the southern region, higher Charlson Comorbidity Index (CCI) score, history of chronic kidney disease, chronic liver disease, malnutrition, portal hypertension, and alcohol use.

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Structured alcohol cessation support program versus current practice in acute alcoholic pancreatitis (PANDA): Study protocol for a multicentre cluster randomised controlled trial.

This is the first multicentre trial with a cluster randomised trial design to investigate whether a structured alcohol cessation support program reduces recurrent acute pancreatitis in patients after a first episode of acute alcoholic pancreatitis, as compared with current practice.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Am J Clin Nutr

New insights into mechanisms of vitamin B12 uptake and conversion.

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Red meat and type 2 diabetes: do methodological advancements sufficiently increase the certainty of evidence?

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Inflamm Bowel Dis

Dietary Inflammatory Indices Are Not Associated With Inflammatory Bowel Disease Incidence and Progression.

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Freeing Time and Reducing Costs: The Value of a Specialized Nursing Service in IBD.

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Get Fit: Muscle Health for Crohn's Disease Surgical Outcome Optimization.

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Transperineal Ultrasonography in the Assessment of Rectal Inflammation: Beyond the Monitoring of Ulcerative Colitis.

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Liver Transpl

Do not underestimate the impact of hepatic hydrothorax on survival before and after liver transplant.

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Factors associated with receiving a liver transplant from deceased donors located far from the transplant hospital.

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Management of patients with cirrhosis in the emergency department: Implications for hospitalization outcomes.

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Pancreas

Design Flaws in Study of Prophylaxis of Postendoscopic Retrograde Cholangiopancreatography Pancreatitis.

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Letters&Replies

Letters to the editors and authors’ replies

Am J Clin Nutr

In randomized controlled trials with nutrient supplementation, participants with subjective memory complaints should not be combined with those having a mild cognitive impairment diagnosis.

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Pancreatology

Association analysis of CUZD1 variants in European chronic pancreatitis patients.

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